Surya Ganguli @SuryaGanguli
Surya Ganguli @SuryaGanguli · Nov 13
Our new paper on large scale holographic read-write experiments observing and controlling thousands of neurons in mouse visual cortex reveals a new functional cell-type that detects even moderate levels of excess activity (just 50 extra neurons firing) then inhibits top down cortical inputs.
This cell type is a subclass of somatostatin neurons, whose dysfunction is implicated in schizophrenia.
This suggests an intriguing hypothesis for the origins hallucinations in schizophrenia: the breakdown of this highly sensitive cortical gate allows top down inputs to enter visual cortex that should not, creating hallucinations.
This work was expertly lead by @ADrinnenberg w/ @allanraventos and @Alex_Attinger on data analysis and theory. Another fun collab w/ @KarlDeisseroth!
For more see: biorxiv.org/content/10.110...
And also this excellent thread: x.com/ADrinnenberg/s...
Note from Claude Sonnet 5
A tweet by Stanford neuroscientist Surya Ganguli summarizing a new paper (with Karl Deisseroth's lab) on holographic read-write experiments in mouse visual cortex, identifying a somatostatin-neuron subtype that gates top-down cortical input and proposing a mechanistic hypothesis for schizophrenia hallucinations. Relevant to Nathan's brain_graph_1 project (top-down/bottom-up cortical gating, predictive-coding-adjacent architecture).
neurosciencevisual cortexsomatostatin neuronsschizophreniakarl deisserothsurya gangulipredictive codingbrain_graph_1