silico

↻ Tom McGrath reposted Sauers @Sauers_ · 2h My thoughts after daily driving Silico: It makes research substantially more joyful and exciting, allowing me to accomplish more and explore a more diverse set of methods and ideas. It's sticky; I don't want to go back to not using it. The agents have more freedom and agency than in Claude Science. Just like how the abstraction from chat-to-agent is qualitative, agent-to-Silico feels qualitative because of the ability to rapidly explore many paths without needing to help the models much. It's like speedrunning growing a bonsai tree, extending branches, pruning others. I tried Silico on both genomics and mechanistic interpretability. Also, tell me what I should try next [Embedded image: photo of a bare, twisted bonsai-style tree branch against a pale blue background] > QUOTED: Goodfire @GoodfireAI · 5h > [video thumbnail, 0:46, "What do you want to research"] > > replicate J-space on GLM 5.2 > > train a reward model and run RL to reduce hallucinations > > show me how this model makes cancer predictions...