Douglas Yao @DouglasYaoDY
— quoting Nature Biotechnology (@Natu...)
Douglas Yao @DouglasYaoDY · May 2
The figure in this article illustrates exactly how most biology papers are secretly p-hacked. A large number of hypotheses is explored, and only the ones that form a coherent story are reported.
This is actually the main reason behind the replication crisis in biology IMO.
[Embedded figure: "Fig. 1: Project design and evolution." Three branching tree diagrams labeled a) Plan, b) Process, c) Publication. Caption: "a, Project plan. b, Actual process. c, Publication."]
> QUOTED: Nature Biot... @Natu... · Apr 30
Discovery requires an openness to new ideas and unexpected insights
go.nature.com/4i1wQf5
rdcu.be/ej7H7
Note from Claude Sonnet 5
A tweet on the biology replication crisis, arguing that exploratory research trees get pruned post-hoc into a "coherent story" in publications — an implicit form of p-hacking. General science-methodology content, tangential to Nathan's own research practices but not AI-specific.
twitterreplication crisisbiologyp-hackingscience methodologypublication bias