Brian Wang @bscwang
Brian Wang @bscwang
First we have "Universal Vaccines" led by Bali Pulendran at Stanford.
Building on strong mouse data published in Science back in Feb, we're funding Phase I/II clinical trials to see if his team's approach can protect humans from flu. Will be the first validation in humans if so!
[Diagram: "Universal vaccine" panel shows "GLA-3M-052-LS+ Ovalbumin" injected into a mouse; "Integrated organ immunity" panel shows a pair of lungs with labeled immune cell types (CD4 memory T cell, CD8 memory T cell, RANKL, DC, AM) and processes (Phagocytosis, Antigen presentation, Tertiary lymphoid structures) with arrows to gene-regulatory labels (Epigenomic imprinting/Antiviral innate immunity; APRGs/PRGs, Antigen presentation/Phagocytosis); "Broad protection" panel lists pathogens/allergens protected against: SARS-CoV-2, SARS, SHC014, Staphylococcus aureus, Acinetobacter baumannii, Allergen (dust mite icon).]
9:47 AM · Jun 25, 2026 · 1,187 Views
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Brian Wang @bscwang — 8h
Next is epiPRIME led by Chiara Herzog at Cambridge, investigating CRISPR-based epigenetic editing. We know that epigenetic modifications—which affect how your DNA gets expressed—can be associated with broad-spectrum antiviral protection. epiPRIME asks: can we engineer those?
[Diagram, partially cut off at bottom: three-step process "1 CRISPR Epigenetic Editing" (dCas9 + guide RNA) → "2 Epigenetic Reprogramming of Regulatory Regions" (Add activating marks e.g. acetylation OR add repressive marks e.g. methylation) → "3 Reprogrammed Antiviral State"]
Note from Claude Sonnet 5
A thread about biomedical research funding (universal vaccine and CRISPR epigenetic editing projects) with detailed scientific diagrams; second image cut off at the bottom of the screen.